When age, gender, AML subtype, ELN risk group, CBF rearrangements, hematologic parameters, treatment, TOX, TOX2, TOX3, and TOX4 were included in univariate COX regression analysis, only age, TOX2, TOX3, and TOX4 were significantly associated with poor overall survival in AML patients. The gene discussed is TOX3; the disease is acute myeloid leukemia.