When age, gender, AML subtype, ELN risk group, CBF rearrangements, hematologic parameters, treatment, TOX, TOX2, TOX3, and TOX4 were included in univariate COX regression analysis, only age, TOX2, TOX3, and TOX4 were significantly associated with poor overall survival in AML patients. Here, TOX4 is linked to acute myeloid leukemia.