CTLA4 and neoplasm: It has been shown that in the tumor microenvironment, tumor cells induce the expression of immune checkpoint (IC) genes, such as programmed cell death protein 1 (PD-1), cytotoxic T lymphocyte-associated molecule-4 (CTLA-4), and lymphocyte-activation gene 3 (LAG-3), leading to T cell exhaustion and immune escape (4–9).