In addition, the GSEA demonstrated that linoleic acid/alpha linolenic/glycerophospholipid metabolism and oxidative phosphorylation were significantly enriched in the high-risk model, whereas tight/adherens junction, renal cell carcinoma, ERBB signaling pathway, and the TGF beta signature pathway were enriched in the low-risk model. Here, EGFR is linked to hereditary clear cell renal cell carcinoma.