For example, SOX9 is a key transcription factor and related with chemoresistance (46); HMGB2 is known to bind to DNA structure resulting from cisplatin-DNA adducts and affect the chemosensitivity of cells (47); CD44 is related with stemness of cancer cells (48); S100A4 and CTGF are related with fibroblast in tumor microenvironment (43, 49). The gene discussed is CCN2; the disease is cancer.