Sex [OR: 7.19 (95% CI 3.10, 16.68)], AFP [OR: 62.03 (95% CI 8.20, 469.70)], albumin [OR: 3.32 (95%CI 1.50, 7.34)], viral hepatitis (HBsAg or HCV-Ab positive) [OR: 48.69 (95% CI 1.50, 7.34)], DBIL [OR: 4.08 (95% CI 1.72, 9.70)] and sonographic score [OR: 3.63 (95% CI 2.37, 5.57)] were significantly different between HCC and IPT with p < 0.01. The gene discussed is ALB; the disease is hepatocellular carcinoma.