Then, we investigate the correlation between ASXL2 expression and clinicopathological factors using logistic regression analysis and found that elevated ASXL2 expression levels in PAAD were correlated with tumor grade (G4 vs G1, P = 0.002) and ASXL2 DNA methylation (P < 0.001, Table 1). This evidence concerns the gene ASXL2 and neoplasm.