Similar findings were observed for M1 macrophage infiltrates (CD2: Rho=0.760, CD3D: Rho=0.706, CD3E: Rho=0.747, and CXCR6: Rho=0.744) and M2 macrophages (CD2: Rho=0.753, CD3D: Rho=0.667, CD3E: Rho=0.748, and CXCR6: Rho=0.715), being the association with M2 macrophages higher than those observed for HPV-positive HNSCC tumors. This evidence concerns the gene CXCR6 and head and neck squamous cell carcinoma.