We identified a positive correlation between the new immune gene signature (CD2, CD3D, CD3E, CXCR6) and CD274 (PD-L1) expression in HNSCC patients (Spearman rank correlation coefficient = 0.56; P=2.4E-43), which could support the outcome prediction in this group. Here, CD2 is linked to head and neck squamous cell carcinoma.