In HPV-positive HNSCC tumors (n=98), we observed the strongest positive correlation with central memory CD8+ T cell subpopulation (CD2: Rho=0.904, CD3D: Rho=0.933, CD3E: Rho=0.938 and CXCR6: Rho=0.886) and also a positive correlation with effector memory CD8+ T cells (CD2: Rho=0.612, CD3D: Rho=0.693, CD3E: Rho=0.623 and CXCR6: Rho=0.606) (Figure 3). The gene discussed is CD2; the disease is head and neck squamous cell carcinoma.