In case of HPV-negative HNSCC tumors (n=422), we found a positive correlation between the gene expression level of CD2, CD3D, CD3E, and CXRC6, and CD8+ T cells subpopulations, finding the higher correlation with CD8+ central memory cells (CD2: Rho=0.817, CD3D: Rho=0.800, CD3E: Rho=0.826, and CXCR6: Rho=0.797). This evidence concerns the gene CXCR6 and head and neck squamous cell carcinoma.