The fact that some genes correlated better than the whole signature let us explore a combination of transcripts that could increase the prediction capacity, and this was the case for a signature that included only four genes: CD2, CD3D, CD3E, and CXCR6. Of note, these findings were reproduced in CSCC and with minor significance in esophagus tumors. This evidence concerns the gene CXCR6 and neoplasm of esophagus.