TP53 and non-small cell lung carcinoma: To this end, we stably suppressed Set7/9 expression [knock-down (KD) or knock-out (KO)] in three NSCLC cell lines with different p53 status [H1299 (p53-null), A549 (wild-type p53), and H1975 (mutant R273H p53)] (Figure 2A and Supplementary Figure S1).