CD274 and bone metastasis: After multivariate analysis, the results showed that PD-L1 inhibitors (HR: 2.37; 95%CI, 1.10, 5.11; p = 0.03), ECOG PS ≥ 2 (HR: 6.96; 95%CI, 2.25, 21.55; p = 0.001), liver metastasis (HR: 2.66; 95%CI, 1.19, 5.93; p = 0.02), bone metastasis (HR: 4.61; 95%CI, 2.01, 10.59; p < 0.001), and LIPI intermediate/poor (HR: 2.34; 95%CI, 1.13, 4.86; p = 0.02) were independent risk factors for OS (Table 4).