We observed that glycolytic subtype harbors higher mutational ratio of TP53 [35/83 (42.2%) vs. 39/158 (24.7%), p=0.008], but a significant lower mutational ratio of CTNNB1 [5/83 (6.0%) vs. 65/158 (41.1%), p= 2.75e-08] than KB-metabolic subtype in HCC (Figure 4A). The gene discussed is CTNNB1; the disease is hepatocellular carcinoma.