Graves’ disease is an autoimmune thyroid disorder, characterized by the presence of autoantibodies to the thyrotropin receptors (TRAb), which stimulates TRAb and leads to clinical manifestations of hyperthyroidism. While some of the cutaneous manifestations seen among patients with Graves’ disease are due to excess thyroid hormone, certain extrathyroidal manifestations occur due to the effect of thyroid-stimulating immunoglobulins on TRAb found in the skin and connective tissue. This evidence concerns the gene TSHR and Graves disease.