MEN1: multiple endocrine neoplasia type 1; MEN2: multiple endocrine neoplasia type 2; NF1: neurofibromatosis 1; POEMS: Polyradiculoneuropathy, Organomegaly, Endocrinopathy, Monoclonal plasma cell disorder, and Skin changes; NLD: necrobiosis lipoidica diabeticorum. The gene discussed is MEN1; the disease is endocrine system disorder.