N: Total study population; I: intervention group; C: control group; RRMS: Relapsing-Remitting Multiple Sclerosis; SPMS: Secondary Progressive Multiple Sclerosis; EDSS:  Expanded Disability Status Scale; IFN: Interferon; MRI: Magnetic Resonance Imaging; SC: Subcutaneous; IM: Intramuscular. This evidence concerns the gene IFNA1 and multiple sclerosis.