A total of 194 ESRD patients participated in a cross-sectional study in a Palestinian hospital. Due to their ESRD, they were undergoing dialysis (both hemodialysis and peritoneal dialysis) on a regular basis. Among them, 42.8% of patients developed osteoporosis, while 40.2% developed osteopenia. However, patients aged >60 years had a higher percentage of PTH, osteopenia, and osteoporosis. The gene discussed is PTH; the disease is Osteopenia.