The pattern of TAM development in glioma started first with a microglia phenotype (P2RY12+/TMEM119+), then it turned to polarized macrophage (CD163+), and finally converged into M2b macrophages (IL1RN+) with activated expression of strong angiogenesis signaling molecules (VEGFA). The gene discussed is P2RY12; the disease is central nervous system cancer.