For example, we identified a subnetwork involving endothelial IL33 ↔ macrophage CXCL13 ↔ fibroblast CDKN1A; each component within this subnetwork is associated with vasculopathy [70–72], and here we suggest that they interact during metabolic pathology in the aorta. Here, CXCL13 is linked to vascular disorder.