Interestingly, the four CPP-causing mutations in MKRN3 seemed to have little or no effect on the interaction between MKRN3–MBD3 (Supplementary Fig. 3D), suggesting that these mutations might cause CPP through mechanisms other than directly affecting the MKRN3–MBD3 interaction. The gene discussed is MKRN3; the disease is central precocious puberty.