This went a step further from the previous findings that MBD3-bound gene loci highly overlapped with 5hmC-rich chromosomal regions [15,17,19,22,40,41], which might mechanistically underlie why MBD3 mutations or aberrances in the 5hmC distribution pattern were associated with human disease, including cancer [21,42–46] and ASD [20,47]. Here, MBD3 is linked to cancer.