NR4A1 and melanoma: They also demonstrated that the compound THPN (1-(3,4,5-trihydroxyphenyl)nonan-1-one) from their compound library triggers the movement of Nur77 into the mitochondria by interaction with Nix, where Nur77 is located in the mitochondrial inner membrane and interacts with ANT1, and then causes the opening of the mitochondrial permeability transition pore and the depolarization of the mitochondrial membrane, eventually leading to the irreversible autophagic death of melanoma cells.