Two years later using TALENs, Ke et al. successfully generated a biallelic microcephalin 1 (MCPH1) mutant cynomolgus monkey that recapitulated most of the clinical characteristics observed in individuals with microcephaly: smaller head circumference, hypoplastic corpus callosum, premature chromosome condensation and behavioral abnormalities [42]. Here, MCPH1 is linked to microcephaly.