Since G9a can have activities associated with either promoting or suppressing metastatic behaviors, additional work is needed to assess whether G9a truly promotes metastasis through methylation, or if it acts as a repressor to HOX genes in melanoma, and whether these distinct activities may be dependent upon the context of other genomic aberrations within tumor cells, or perhaps within the microenvironment of the tumor. Here, EHMT2 is linked to melanoma.