However, the widely used cholesterol chelator HP-β-CD, which was effective in cell and mouse models of NPC [34,35], failed to ameliorate cerebellar degeneration and motor deficits in Snx14-deficient mice (Fig. S13G–I), which suggests that SNX14 deletion induces SCAR20 by signaling pathways other than regulation of the accumulation of unesterified cholesterol. The gene discussed is SNX14; the disease is nasopharyngeal carcinoma.