For example, in bleomycin-induced mouse lung fibrosis, Notch 1 and Jagged 1 are highly expressed in fibrotic lungs compared to control normal lungs, and mesenchymal Notch 1 conditional genetic deletion partially diminished bleomycin-induced lung fibrosis and reduced myofibroblast differentiation. This evidence concerns the gene JAG1 and pulmonary fibrosis.