When analyzing the pathogenesis of psoriasis vulgaris, it is difficult to state unequivocally whether bothersome skin changes are the result of changes in the level of plasma signaling molecules, including proinflammatory cytokines, factors stimulating KC proliferation, as well as angiogenesis, or whether changes in the level of these factors in the plasma result directly from changes in epidermal cell metabolism [3]. Here, CALCA is linked to psoriasis vulgaris.