Kachi et al. reported a case that foveal thickness of one patient with RVO-ME was decreased by 53.42% after 8 intravenous injections of infliximab, a TNF-α antibody, while the macular edema relapsed after discontinuation of infliximab, indicating TNF-α, as an inflammatory factor, that was involved in the pathogenesis of RVO-ME [28]. The gene discussed is TNF; the disease is macular retinal edema.