We found that in RA patients, four miRNAs (miR-520h, miR-498, miR-548n, and miR-19b-3p) were differentially expressed after anti-TNF treatment, while fourteen were differentially expressed in AS patients (miR-130a-3p, miR-146a-5p, miR-21-5p, miR-22-3p, miR-23a-3p, miR-30a-5p, miR-362-3p, miR-548ah-5p, let-7c-5p, let-7f-5p, miR-125a-5p, miR-18a-5p, miR-374b-5p, and miR-98-5p). This evidence concerns the gene TNF and rheumatoid arthritis.