The hub genes detected in comparison between RA and AS patients after therapy linked to downregulated, as well as upregulated microRNAs were TP53, AKT1, MYC, EGFR, and CTNNB1, although downregulated microRNAs were also related to UBC, PTEN, CCND1, HSPA8, and VEGFA and upregulated to MAPK1, JUN, HDAC1, NOTCH1, and MAPK8. The gene discussed is MAPK8; the disease is rheumatoid arthritis.