HOTAIR and arthritic joint disease: Other studies established a role of EVs as biomarkers in arthritis by showing an association of exosomal amyloid A and lymphatic vessel endothelial hyaluronic acid receptor-1 with disease activity in RA [14] and identified higher expression of long noncoding RNA, HOX Transcript Antisense RNA (HOTAIR), in serum exosomes of RA cases [15].