In comparison between RA and AS patients before treatment, downregulated microRNAs were connected to TP53, AKT1, MYC, UBC, EGFR, RPS27A, MAPK1, UBB, HSPA8, and PTEN, while upregulated microRNAs were linked to HSP90AA1, CCNB1, STAT3, CDC5L, MDM2, CASP3, ATM, SKP1, ACTB, and IGF1R. The gene discussed is MAPK1; the disease is rheumatoid arthritis.