In summary, the final result of the study shows that uremia can gradually lead to myocardial hypertrophy and TLR4 and MyD88 are highly expressed in serum, kidney, and myocardial tissues of uremic rats, suggesting that TLR4 and MyD88 may be related to the degree of uremia and the degree of disease caused by it. Here, TLR4 is linked to cardiac hypertrophy.