The results showed that, in the kidney tissue, the expression level of MyD88 in rats in the mock surgical group and the uremia group was higher than that in the normal control group, the MyD88 level in the uremia group was higher than that in the mock surgical group, and the level of TLR4 in the uremia group 12 w group was higher than that of the uremia group 4 w group. Here, TLR4 is linked to uremia.