In the hormonal therapy, bicalutamide is an antiandrogen agent that achieves the purpose of treatment by preventing the action of endogenous androgens on the prostate, and goserelin acetate is a GnRH-agonist that can cause a dramatic increase in testosterone in early treatment, exert a combined effect with bicalutamide, and block androgens after testosterone decrease, thereby inhibiting tumor growth. This evidence concerns the gene GNRH1 and neoplasm.