Rats in the RDN group (155.98 ± 30.07 vs. 218.46 ± 47.36 pg/ml; P=0.016), the Nog group (130.64 ± 34.29 vs. 218.46 ± 47.36 pg/ml; P=0.002), and the NEP group (124.96 ± 18.29 vs. 218.46 ± 47.36 pg/ml; P=0.001) had significantly lower plasma NT‐proBNP levels than those in the HF group. This evidence concerns the gene NPPB and hydrops fetalis.