NLRP1 and Alzheimer disease: Additionally, it has been reported that acupuncture may attenuate cognitive defects in an Alzheimer's disease (AD) mouse model by inhibiting NLRP1 inflammasome-mediated pyroptosis [38], which is indirectly in line with our findings because both acupuncture and Tuina share the similar therapy mindset of stimulating meridians and collaterals along the body surface.