Additionally, it has been reported that acupuncture may attenuate cognitive defects in an Alzheimer's disease (AD) mouse model by inhibiting NLRP1 inflammasome-mediated pyroptosis [38], which is indirectly in line with our findings because both acupuncture and Tuina share the similar therapy mindset of stimulating meridians and collaterals along the body surface. This evidence concerns the gene NLRP1 and early-onset autosomal dominant Alzheimer disease.