Multivariate Cox regression analysis was conducted to develop a novel signature using fifteen cancer stemness-related genes (including RAB31, COL6A3, COL5A2, CCDC80, ADAM12, VGLL3, ECM2, POSTN, DPYSL3, PCDH7, CRISPLD2, COLEC12, NRP2, ISLR, and CCDC8) for prognosis prediction of COAD using the train cohort. The gene discussed is COL6A3; the disease is colon adenocarcinoma.