Multivariate Cox regression analysis was conducted to develop a novel signature using fifteen cancer stemness-related genes (including RAB31, COL6A3, COL5A2, CCDC80, ADAM12, VGLL3, ECM2, POSTN, DPYSL3, PCDH7, CRISPLD2, COLEC12, NRP2, ISLR, and CCDC8) for prognosis prediction of COAD using the train cohort. Here, COL6A3 is linked to cancer.