WDTC1 and diabetes mellitus: As the study progressed, the body weight of the SHR diabetic control (SHR+STZ) and SHR diabetic treated groups including SHR+STZ+Irb, SHR+STZ+Pio, SHR+STZ+Adp, SHR+STZ+Adp+Irb, and SHR+STZ+Adp+Pio follows a significantly decreasing body weight pattern with the duration of diabetes, irrespective of various treatments as compared to day 0 and control groups on days 8, 21, and 28 of the study (P < 0.05) (Table 1).