For the first group that contained 17 KP variants in 23 carriers, we found five individuals with matching phenotypes: prolonged QTc interval (Arg366Trp in KCNQ1 and Arg858His in CACNA1C), hypertriglyceridemia (Gln313Ter in APOA5), CAD (Pro279Leu in MEF2A), and cerebral infarction (Arg153Cys in NOTCH3). Here, APOA5 is linked to brain infarction.