Tregs acquire a phenotype and expression profile resembling Th1 cells, thereby contributing to disease progression (235): Lower expression levels of Foxp3, TGF, CTLA-4 and CD39 were accompanied by an increase in IFN secretion in relapsing-remitting MS (RRMS) patients (236–238). This evidence concerns the gene CTLA4 and relapsing-remitting multiple sclerosis.