TRAC and graft versus host disease: Endogenous TCRA and β-2 microglobulin(B2M) genes are disrupted simultaneously by applying CRISPR RNA electroporation to manufacture UCAR-T cells, which are both TCR and MHC-I negative, aiming to evade rejection and deliver antileukemic effects without GVHD, but the results of these studies are still unpublished.