So while the link with immunosuppressive macrophages and CRC is not disputed, these cells are not identical to in vitro differentiated M(IL4)s; yet, the similarity between M(IL4)s and TAMs [e.g. both make TGFβ (46)], raises the possibility that M(IL4)s could promote CRC. The gene discussed is TGFB1; the disease is colorectal carcinoma.