The data herein, confirm and extend the anti-colitic effect of intraperitoneal delivery of M(IL4)s, and reveal that these cells, under the paradigms tested, did not boost tumor development in the azoxymethane (AOM)/DSS model of CRC, or immune cell infiltration and lung histopathology in the ovalbumin model of airway hypersensitivity. Here, IL4 is linked to neoplasm.