Consistent with previous findings in this model (13), mice treated with M(IL4)s had significantly less severe DNBS-induced colitis (Figures 1C, –E), a range of benefit consistent with prior investigations (12–14), and these observations are supported by significantly reduced infiltration of Ly6G+ cells and colonic MPO levels in tissues from M(IL4)+DNBS treated mice compared to tissue from DNBS-only treated mice (Figures 1F, G). This evidence concerns the gene MPO and colitis.