EBV envelope proteins including gH/gL, gB, gp350 play key roles in EBV entry and infection of its target cells, and neutralizing antibodies elicited by each of these proteins have shown to prevent EBV infection of target cells, markedly decrease EBV titers in the blood of humanized mice, and prevent their death after challenge with lethal dose EBV. This evidence concerns the gene ERVW-1 and infection.