MMP1 and cancer: When all TCGA cancer patients were stratified based on high (top 25%) or low (bottom 25%) tumoral mRNA expression of MMP1, MMP9, collagen I and LAIR-1 (Supplementary Figure 2), patients with MMPhighCOL1A1highLAIR1high tumors showed significantly worse overall survival compared to patients with MMPlowCOL1A1lowLAIR1low tumors (Figures 1A, B).