To note, the main predisposing risk factor for MS in North Europeans is the HLA-DRB1*15 (*DRB1-15:01-DQB1*06:02), while in Sardinian population the predisposing *15:01 is virtually absent and MS is associated in particular to *13:03-*03:01, *04:05-*03:01, and *03:01-*02:01 (4, 5). This evidence concerns the gene HLA-DRB1 and myeloid sarcoma.