NLRP3 and Parkinson disease: Pathogenic protein aggregates, such as α-syn fibrils, another hallmark of PD pathology and the primary component of Lewy bodies, were reported to activate NLRP3 inflammasome in microglia through an interaction with toll-like receptors (TLRs) and the activation of nuclear factor kappa-B(NF-κB) (9, 10).