In addition, IL-27 can also increase the content and ratio of Th1 and Th17 cells, thus leading to the excessive secretion of inflammatory mediators in local tissues, such as IFN-γ, CXCL10, and TNF-α, Thereby forming an inflammatory cascade that eventually induces autoimmune diseases (55, 56). Here, CXCL10 is linked to autoimmune disease.