The six-transmembrane protein of the prostate 2 (Stamp2), also known as six-transmembrane epithelial antigen of prostate 4 (STEAP4), has emerged as a regulator of leukocyte-driven inflammation in metabolic syndrome (13) atherosclerosis (14), and pulmonary vascular remodeling (15). The gene discussed is STEAP4; the disease is metabolic syndrome.