However, the activation of Aim2 and Nlrp3-inflammasomes are repressed in macrophages infected with F. tularensis LVS, and both are dispensable for vaccine-induced immunity against pulmonary tularemia (Atianand et al., 2011; Dotson et al., 2013; Wallet et al., 2016; Alqahtani et al., 2021). Here, NLRP3 is linked to tularemia.