The notable ones were surface receptors Dec-205, Tlr1, Tlr5, Tlr11, the cytosolic receptors Nod2, Nlrp1a, Naip2, the DNA-sensing pathway components cGas, Sting, Aim2, and the components of NF-κβ and MAPK-signaling pathway genes CD40l, Rsagrp1 and pik3cg. The transcript levels of all these genes were upregulated in the Nlrp3−/− mice on day 7 post-infection. The gene discussed is PIK3CG; the disease is infection.