In 2019, SARS-CoV-2 [which has a NSPRRAR↓SV furin cleavage site, and bat or pangolin are suspected as natural hosts (Zhang et al., 2020; Zhou P. et al., 2020)] caused the COVID-19 pandemic and sent stronger warnings for the threat of CoVs with furin cleavage sites to human beings or animals. Here, FURIN is linked to COVID-19.