Hexokinase 2 (HK2; FC = −3.4), succinate dehydrogenase complex, subunit C (SDHC; FC = −3.1), isocitrate dehydrogenase 1 (IDH1; FC = −1.8), and pyruvate kinase muscle (PKM; FC = 1.5) were all downregulated in individuals with diabetes. This evidence concerns the gene PKM and diabetes mellitus.