Hypoglycemia, also known as an insulin reaction or insulin shock, is a clinical and biological syndrome caused by an abnormal decrease in plasma glucose levels to below 70 mg/dl and responsible for non-specific signs and symptoms, including shakiness, nervousness, sweating, chills and clamminess, dizziness, hunger and nausea, confusion, weakness, sleepiness, seizures, and loss of consciousness (17, 18). The gene discussed is INS; the disease is Hypoglycemia.