ESR2 and neoplasm: A previous meta-analysis of immunohistochemical studies correlated ERβ expression with high grade (OR=2,169; p<0,001) and muscle-invasive (OR=3,104, p<0,001) tumours (31) and revealed associations between ERβ expression and worse recurrence-free (HR=1,573; p=0,013) and progression-free (HR=4,148; p=0,089) survivals in patients with NMIBC.