In summary, although there are relatively few studies on the relationship between blood neurofilament levels and the prognosis of ALS, blood neurofilament levels (NfL/pNfH) may be good predictive biomarkers of ALS patients; that is, higher blood neurofilament levels may be linked to faster DPR and higher risk of death in ALS patients. This evidence concerns the gene NEFL and amyotrophic lateral sclerosis.