Similarly to CaMKII Knock out mice, RyR2-S2814A knock-in mice were protected against abnormal SR Ca2+ leak and HF after transverse aortic constriction (TAC) (van Oort et al., 2010) but surprisingly not after myocardial infarction (MI) (Respress et al., 2012). Here, CAMK2G is linked to myocardial infarction.