RYR2 and hydrops fetalis: ROS oxidation of RyR2 during HF induces the dissociation of FKBP12.6 leading to the aberrant Ca2+ release (Shan et al., 2010a), although other groups showed that RyR2 oxidation induces CaM dissociation without changing FKBP12.6 binding (Ono et al., 2010; Oda et al., 2015).