On a rabbit model of HF, increased SR Ca2+ leak (Mazurek et al., 2014) and Ca2+ waves (Bovo et al., 2015) could be attributed to an increase in RyR2 intersubunit disulfide cross-linking (Mazurek et al., 2014; Bovo et al., 2015, 2018). The gene discussed is RYR2; the disease is hydrops fetalis.