RYR2 and myocardial infarction: Similarly to CaMKII Knock out mice, RyR2-S2814A knock-in mice were protected against abnormal SR Ca2+ leak and HF after transverse aortic constriction (TAC) (van Oort et al., 2010) but surprisingly not after myocardial infarction (MI) (Respress et al., 2012).