Recently, evidences that S2808 is not the only target for RyR2 phosphorylation by PKA have been put forward; S2030 seems to be a potent target of PKA (Potenza et al., 2019) and can be involved in the progression of HF (Xiao et al., 2006; Benkusky et al., 2007). Here, RYR2 is linked to hydrops fetalis.