Interestingly, PA-induced increased SIRT1 was also observed in animal models of myocardial infarction, and was associated with a reduction of apoptotic markers and overall myocardial damage (Donniacuo et al., 2019), suggesting that SIRT1 could play a role in mediating the beneficial effects of PA after ischemic myocardial damage. Here, SIRT1 is linked to myocardial infarction.