SIRT1 and atherosclerosis: Multiple single nucleotide polymorphisms (SNPs) of the SIRT1 gene have been found to associate with ASCVD: the polymorphisms rs7069102 C>G, localized in the intron 4, and rs2273773 C>T, localized in the exon 5, are associated with an increased risk of sCAD, an increased level of circulating SIRT1 and a reduced expression of eNOS (Kilic et al., 2014).