To further investigate the effects of CSE-induced ROS on inflammatory cytokines and to determine whether it was subjected to the regulation of STIM1, we examined the effects of STIM1 knockdown and NAC pretreatment on IL-8 and IL-1β, two important cytokines in the pathogenesis of COPD, in PMA-differentiated THP-1 cells (Pauwels et al., 2011). The gene discussed is STIM1; the disease is chronic obstructive pulmonary disease.