FMR1 and Anxiety: In other Fmr1 KO mouse studies, OV101 also normalized hyperactivity and repetitive, social, and anxiety-like behavior, which have been associated with decreased expression of the GABAA receptor δ subunit and deficient GABAergic tonic inhibition (Gantois et al., 2006; Olmos-Serrano et al., 2010; Martin et al., 2014).