Relationships between anxiety and FMRP level and ASD status may help to stratify patients with FXS in clinical studies (Budimirovic et al., 2017; Budimirovic et al., 2020), with results of this study showing that participants taking OV101 5 mg QD or BID achieved greater improvements in problem behaviors then those receiving the highest dosage (5 mg TID). The gene discussed is FMR1; the disease is fragile X syndrome.