FDX1 and neoplasm: In this study, our data showed that KD-FDX1 cells and WT-FDX1 cells had no difference in terms of growth, apoptosis rate, and cell cycle distribution, while it was involved in other cellular aspects, including aberrant energetics, tumor-associated inflammation, and changes in the immune microenvironment (Hanahan and Weinberg, 2011; Boroughs and DeBerardinis, 2015).